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KMID : 0381219790110020019
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Journal of RIMSK
1979 Volume.11 No. 2 p.19 ~ p.28
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Immunological Studies of Chronic Palatine Tonsillitis
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Abstract
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Although there have been numerous amounts of experimental works, suggesting the immunologic function of the tonsil, no remarkable immunologic changes have been proofed clinically in the patients suffering from chronic tonsillitis.
For example, embryologically the tonsil originate from 2nd branchial pouch where is closely contact with 3 rd branchial pouch, from where the thymus originate. And it is a portion of Waldeyer´s ring around the pharnyx in anatomical viewpoint (Baik, et al., 1977). Histologically it is a component of lymphoepithelial system, such as thymus, Fabricius bursae of the birds, vermiform appendix of the rabbits and Payer´s patch-,of the human being (Harrison, et al., 1970; Harrison, 1970). There were authors, who insisted tonsil was the most active immunologic organ in the early of life (Codrik and Platt, 1971).
Among the tonsillar cells, the 90% are lymphocytes at the varying stage of development. About 4000 are T-cells and 60°o B. cells (Codrick and Platt, 1971; Sun Lim, et al, 1973; Morag and Ogra, 1975; Surjan and Surjan, 1971). Morag and Ogra, 1975, summerized and reported about localization of B cells containing various immunoglobulins, which reported by various authors with immunofluorescent methods. (Morag and Ogra, 1975; Zucker-Franklin and Berney, 1972; Pesak, 1971; Surjan, et al., 1972: Clilin and Sasaki, 1969: Toda and Ishizaka, 1970; Wicher, et al., 1970; Watanabe, et al, 1974; Bechet, et al, 1974). Sloyer, et al. (1974) and Ogra (1971) reported that the isolated T cells from tonsil make B cell to synthesize the antibody for hapten-protein conjngates in vitro. Surjan and Surjan observed activated lymphocytic proliferation within tonsil after contact with reviously sensitized antigen (diphtheria toxoid), Oettgen, et al. (1966) induced lymphoblastogenesis of them with stimulation by phytohemoagglutinin and streptolysin S, and Morag, et al. (1975) confirmed that they formed rosette with nonsensitized sheep´s erythrocytes in vitro.
Baik, et al., 1977, reported without control data the serum IgG, IgM and IgA level in chronic tonsillitis, as 1, 058 mg/l00 ml, 110.7 mg/100 ml and 219.6 mg/100 ml, respectively, which values are within normal limits, reported by several authors (Kawai, 1973; Stiehm and Fudenberg, 1966; Raphael, et al., 1976). And Kim, 1977, reported rosette positivity in the patients suffering with chronic tonsillitis, as 60.0±5.2%, which values are also within normal limits according to several authors (Jonda, et al., 1972; Kim, 1976; Jonsson, 1974).
In order to confirm the immunologic changes during the recovery and chronic stage of the tonsillitis, the authors collected 49 cases, who were suffered from acute episode of tonsillitis 3 months ago. They had any history of infection or inflammation, except above-mentioned tonsillitis. No vaccination was performed during this 3 months duration. A venepuncture was performed before operation to check leukocytes, rosette test, and serum level of ASO titer and immunoglobulins. Histologic studies, including immunofluorescent staining, was performed on the resected tonsillar tissue.
The followings were ensued;
1. ASO titers of the patients with chronic tonsillitis were remarkably increase than that of control group (p2. In patients with chronic tonsillitis, the rosette positivity, . absolute rosette-positive lymphocytes and serum level of IgG were in the trend of decrease than that of normal control group.
3. There were decreasing tendency in the number of IgG and IgA bearing cells according to the severity of the inflammation in the tonsillar tissue of chronic tonsillitis patients.
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KEYWORD
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